A Mini-Review: MicroRNA in Tendon Injuries

Tendon injury is a difficult clinical problem. Till now, the basic cell biology of tendons is still not fully understood and the management of tendon injury poses a considerable challenge for clinicians. Endogenous microRNAs are short noncoding RNA molecules which can negatively regulate gene expression at the post-transcriptional level. The regulatory role of miRNA has well been studied in many diseases, however the significance of miRNAs in tendon injuries remains elusive. This review summarized the miRNAs related to the pathogenesis of tendinopathy and tendon injuries and highlighted their clinical potential, which may bring new insights into developing a novel advanced strategy toward tendon injury treatment. A Mini-Review: MicroRNA in Tendon Injuries Jia Guo1, Jin-fang Zhang1-3, Gang Li1-5, Kai-ming Chan1,2,4,5* 1Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, PR China 2Lui Che Woo Institute of Innovative Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China 3The Chinese University of Hong Kong, Shenzhen Research Institute, Shenzhen, PR China 4Stem Cells and Regenerative Medicine Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China 5Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, PR China *Corresponding author: Kai-Ming Chan, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, PR China, Tel: 852-26322728; Fax: 852-26463020; E-mail: [email protected] Received July 28, 2015; Accepted September 07, 2015; Published September 09, 2015 Citation: Guo J, Zhang JF, Li G, Chan KM (2015) A Mini-Review: MicroRNA in Tendon Injuries. J Stem Cell Res Ther 5: 303. doi:10.4172/2157-7633.1000303 Copyright: © 2015 Guo J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.